Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: a systematic review and meta-analysis
Article
Article Title | Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: a systematic review and meta-analysis |
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ERA Journal ID | 39808 |
Article Category | Article |
Authors | Denham, Joshua (Author) and Sellami, Maha (Author) |
Journal Title | Ageing Research Reviews |
Journal Citation | 70 |
Article Number | 101411 |
Number of Pages | 13 |
Year | 2021 |
Place of Publication | Ireland |
ISSN | 1568-1637 |
1872-9649 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.arr.2021.101411 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S1568163721001586?via%3Dihub |
Abstract | Telomeres protect genomic stability and shortening is one of the hallmarks of ageing. Telomerase reverse transcriptase (TERT) is the major protein component of telomerase, which elongates telomeres. Given that short telomeres are linked to a host of chronic diseases and the therapeutic potential of telomerase-based therapies as treatments and a strategy to extend lifespan, lifestyle factors that increase TERT gene expression and telomerase activity could attenuate telomere attrition and contribute to healthy biological ageing. Physical activity and maximal aerobic fitness are associated with telomere maintenance, yet the molecular mechanisms remain unclear. Therefore, the purpose of this systematic review and meta-analysis was to identify the influence of a single bout of exercise and long-term exercise training on TERT expression and telomerase activity. A search of human and rodent trials using the PubMed, Scopus, Science Direct and Embase databases was performed. Based on findings from the identified and eligible trials, both a single bout of exercise (n; standardised mean difference [95%CI]: 5; SMD: 1.19 [0.41–1.97], p = 0.003) and long-term exercise training (10; 0.31 [0.03–0.60], p = 0.03) up-regulates TERT and telomerase activity in non-cancerous somatic cells. As human and rodent studies were included in the meta-analyses both exhibited heterogeneity (I2 = 55–87%, p < 0.05). Endurance athletes also exhibited increased leukocyte TERT and telomerase activity compared to their inactive counterparts. These findings suggest exercise training as an inexpensive lifestyle factor that increases TERT expression and telomerase activity. Regular exercise training could attenuate telomere attrition through a telomerase-dependent mechanism and ultimately extend health-span and longevity. |
Keywords | telomere; biological ageing; senescence; TERT |
ANZSRC Field of Research 2020 | 420702. Exercise physiology |
319999. Other biological sciences not elsewhere classified | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Royal Melbourne Institute of Technology (RMIT) |
Qatar University, Qatar | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q6qy4/exercise-training-increases-telomerase-reverse-transcriptase-gene-expression-and-telomerase-activity-a-systematic-review-and-meta-analysis
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