The Emerging Role of Hypoxic Training for the Equine Athlete

Article

Davie, Allan, Beavers, Rosalind, Hargitaiová, Kristýna and Denham, Joshua. 2023. "The Emerging Role of Hypoxic Training for the Equine Athlete." Animals. 13 (17). https://doi.org/10.3390/ani13172799
Article Title

The Emerging Role of Hypoxic Training for the Equine Athlete

ERA Journal ID200143
Article CategoryArticle
AuthorsDavie, Allan, Beavers, Rosalind, Hargitaiová, Kristýna and Denham, Joshua
Journal TitleAnimals
Journal Citation13 (17)
Article Number2799
Number of Pages11
Year2023
PublisherMDPI AG
Place of PublicationSwitzerland
ISSN2076-2615
Digital Object Identifier (DOI)https://doi.org/10.3390/ani13172799
Web Address (URL)https://www.mdpi.com/2076-2615/13/17/2799
AbstractThis paper provides a comprehensive discussion on the physiological impacts of hypoxic training, its benefits to endurance performance, and a rationale for utilizing it to improve performance in the equine athlete. All exercise-induced training adaptations are governed by genetics. Exercise prescriptions can be tailored to elicit the desired physiological adaptations. Although the application of hypoxic stimuli on its own is not ideal to promote favorable molecular responses, exercise training under hypoxic conditions provides an optimal environment for maximizing physiological adaptations to enhance endurance performance. The combination of exercise training and hypoxia increases the activity of the hypoxia-inducible factor (HIF) pathway compared to training under normoxic conditions. Hypoxia-inducible factor-1 alpha (HIF-1?) is known as a master regulator of the expression of genes since over 100 genes are responsive to HIF-1?. For instance, HIF-1-inducible genes include those critical to erythropoiesis, angiogenesis, glucose metabolism, mitochondrial biogenesis, and glucose transport, all of which are intergral in physiological adaptations for endurance performance. Further, hypoxic training could conceivably have a role in equine rehabilitation when high-impact training is contraindicated but a quality training stimulus is desired. This is achievable through purpose-built equine motorized treadmills inside commercial hypoxic chambers. © 2023 by the authors.
Keywordsequine; horse; hypoxia; mitochondria; hypoxia-inducible factor; normobaric; thoroughbred
ANZSRC Field of Research 2020300902. Veterinary anatomy and physiology
300999. Veterinary sciences not elsewhere classified
420702. Exercise physiology
Byline AffiliationsAustralian Equine Racing and Research Centre, Australia
Southern Cross University
Cornell University, United States
School of Health and Medical Sciences
Centre for Health Research
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