Enhanced antibacterial property and osteo-differentiation activity on plasma treated porous polyetheretherketone with hierarchical micro/nano-topography
Article
Article Title | Enhanced antibacterial property and osteo-differentiation activity on plasma treated porous polyetheretherketone with hierarchical micro/nano-topography |
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ERA Journal ID | 1673 |
Article Category | Article |
Authors | Wang, Shengnan (Author), Deng, Yi (Author), Yang, Lei (Author), Shi, Xiuyuan (Author), Yang, Weizhong (Author) and Chen, Zhi-Gang (Author) |
Journal Title | Journal of Biomaterials Science: Polymer Edition |
Journal Citation | 29 (5), pp. 520-542 |
Number of Pages | 23 |
Year | 2018 |
Place of Publication | United Kingdom |
ISSN | 0920-5063 |
1568-5624 | |
Digital Object Identifier (DOI) | https://doi.org/10.1080/09205063.2018.1425181 |
Web Address (URL) | https://www.tandfonline.com/doi/full/10.1080/09205063.2018.1425181 |
Abstract | Implantable polyetheretherketone (PEEK) has great biomedical potential as hard tissue substitute in orthopedic application due to its outstanding mechanical properties and excellent biological stability. However, the poor osseointegration and bacteriostatic ability of implantable PEEK become the major barrier for its wide clinic application. In this study, a hierarchically micro/nano-topographic PEEK with specific functional groups (amino and COOH/COOR) has been fabricated using facile sulfonation combined with argon plasma treatment. The new developed hierarchically micro/nano-topographic PEEK have enhanced hydrophilicity, surface roughness, as well as the high ability of apatite-layer forming. Antibacterial assessment shows that as-treated samples exhibit better antibacterial activity. The cellular responses in osteoblast-like MG-63 cells culturing experiment reveal that the micro/nano-topography accompanied with specific functional groups improves the cell adhesion at the initial stage, further ameliorates proliferation and osteogenic differentiation of MG-63. This study proposes a promising approach to increase osteo-differentiation activity and bacteriostasis of PEEK via synergistic effects involving surface topologic structure and chemical modification, which shows great potential in developing advanced implantable materials. |
Keywords | polyetheretherketone; micro; nano-topography; argon plasma; osteogenic differentiation; bacteriostasis |
ANZSRC Field of Research 2020 | 401605. Functional materials |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Sichuan University, China |
Centre for Future Materials | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q48v6/enhanced-antibacterial-property-and-osteo-differentiation-activity-on-plasma-treated-porous-polyetheretherketone-with-hierarchical-micro-nano-topography
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