Bioinspired, biocompatible and peptide-decorated silk fibroin coatings for enhanced osteogenesis of bioinert implant
Article
Article Title | Bioinspired, biocompatible and peptide-decorated |
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ERA Journal ID | 1673 |
Article Category | Article |
Authors | Wang, Chunyan (Author), Wang, Shengnan (Author), Yang, Yuanyi (Author), Jiang, Zhuo (Author), Deng, Yi (Author), Song, Shaoli (Author), Yang, Weizhong (Author) and Chen, Zhi-Gang (Author) |
Journal Title | Journal of Biomaterials Science: Polymer Edition |
Journal Citation | 29 (13), pp. 1595-1611 |
Number of Pages | 17 |
Year | 2018 |
Place of Publication | United Kingdom |
ISSN | 0920-5063 |
1568-5624 | |
Digital Object Identifier (DOI) | https://doi.org/10.1080/09205063.2018.1477316 |
Abstract | In this study, we develop an osteopromotive polyetheretherketone (PEEK) implant decorated with silk fibroin and bone forming peptide, in which the surface of bioinert PEEK implant is firstly sulfonated to form a three-dimensional, porous topography and then is functionalized with silk fibroin via spin-coating process and peptide decoration. The bio-test results show that cells on the functional bioinert implants exhibit better cell adhesion, proliferation and spreading, when compared with the uncoated ones. Moreover, the peptide-decorated silk fibroin coatings have ability to hasten the osteogenic differentiation and maturation of osteoblast-like cells. Our findings show the potential of the functional PEEK implants with superior bioactivity and osteoinductive property in orthopedics and dentistry. Besides, the facile, bioinspired, osteopromotive modification strategy can be used in other orthopedic and dental implants, such as titanium, zirconium dioxide. |
Keywords | bioinert implant, peptide, silk fibroin, porous, PEEK, osteogenesis |
ANZSRC Field of Research 2020 | 401605. Functional materials |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Sichuan University, China |
Sichuan College of Architectural Technology, China | |
South China Agricultural University, China | |
Shanghai Jiao Tong University, China | |
Centre for Future Materials | |
Institution of Origin | University of Southern Queensland |
Funding source | Australian Research Council (ARC) |
https://research.usq.edu.au/item/q5271/bioinspired-biocompatible-and-peptide-decorated-silk-fibroin-coatings-for-enhanced-osteogenesis-of-bioinert-implant
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