Graphene Oxide and Adiponectin-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Remotely Repeatable Photo-Disinfection
Article
| Article Title | Graphene Oxide and Adiponectin-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Remotely Repeatable Photo-Disinfection |
|---|---|
| ERA Journal ID | 1423 |
| Article Category | Article |
| Authors | Deng, Yi (Author), Gao, Xiangyu (Author), Shi, Xiao-Lei (Author), Lu, Siyu (Author), Yang, Weizhong (Author), Duan, Chunyan (Author) and Chen, Zhi-Gang (Author) |
| Journal Title | Chemistry of Materials |
| Journal Citation | 32 (5), pp. 2180-2193 |
| Number of Pages | 14 |
| Year | 2020 |
| Place of Publication | United States |
| ISSN | 0897-4756 |
| 1520-5002 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1021/acs.chemmater.0c00290 |
| Web Address (URL) | https://pubs.acs.org/doi/10.1021/acs.chemmater.0c00290 |
| Abstract | Biomaterial-associated infection (BAI) is a serious threat to patient health. In general, bacteriostatic agents are loaded on the surface of biomaterials to eliminate BAI; however, the excessive usage of these agents leads to the emergence of drug-resistant bacteria and inadequacy of tissue repair. To address this issue, here, we create a photo-responsive and osteopromotive coating that consists of graphene oxide (GO) nanosheets, polydopamine (pDA) nanolayers, and adiponectin (APN) protein on bioinert sulfonated polyetheretherketone (sPEEK/GO/APN). The functionalized samples display superior cytocompatibility and in viro osteogenicity regarding cell reproduction, spreading, alkaline phosphatase activity, extracellular matrix calcification, and osteo-associated genes expression, outperforming sPEEK/GO and sPEEK/APN samples. The in vivo evaluation using a rabbit femur defect model demonstrates that the multifunctional coating significantly boosts bone regeneration and osseointegration. More importantly, the GO/pDA complex bonded together through π-π stacking and electrostatic interactions gives rise to robust cyclic photothermal bacteria-killing ability towards both Gram-positive and Gram-negative bacteria. Such a surface engineering platform may enable biomedical implants with enhanced osteogenicity ability and remotely recyclable photo-disinfection, holding great potential in the treatment of incurable infective bone loss. |
| Keywords | PEEK; graphene oxide; adiponectin; osteogenicity; photo-disinfection |
| ANZSRC Field of Research 2020 | 401605. Functional materials |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Sichuan University, China |
| Centre for Future Materials | |
| Zhengzhou University, China | |
| Southwest Medical University, China | |
| Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q599v/graphene-oxide-and-adiponectin-functionalized-sulfonated-polyetheretherketone-with-effective-osteogenicity-and-remotely-repeatable-photo-disinfection
Download files
Accepted Version
| 03 - 20200211 - Graphene Oxide and Adiponectin-Functionalized.pdf | ||
| File access level: Anyone | ||
160
total views391
total downloads1
views this month1
downloads this month