Graphene Oxide and Adiponectin-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Remotely Repeatable Photo-Disinfection
Article
Article Title | Graphene Oxide and Adiponectin-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Remotely Repeatable Photo-Disinfection |
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ERA Journal ID | 1423 |
Article Category | Article |
Authors | Deng, Yi (Author), Gao, Xiangyu (Author), Shi, Xiao-Lei (Author), Lu, Siyu (Author), Yang, Weizhong (Author), Duan, Chunyan (Author) and Chen, Zhi-Gang (Author) |
Journal Title | Chemistry of Materials |
Journal Citation | 32 (5), pp. 2180-2193 |
Number of Pages | 14 |
Year | 2020 |
Place of Publication | United States |
ISSN | 0897-4756 |
1520-5002 | |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acs.chemmater.0c00290 |
Web Address (URL) | https://pubs.acs.org/doi/10.1021/acs.chemmater.0c00290 |
Abstract | Biomaterial-associated infection (BAI) is a serious threat to patient health. In general, bacteriostatic agents are loaded on the surface of biomaterials to eliminate BAI; however, the excessive usage of these agents leads to the emergence of drug-resistant bacteria and inadequacy of tissue repair. To address this issue, here, we create a photo-responsive and osteopromotive coating that consists of graphene oxide (GO) nanosheets, polydopamine (pDA) nanolayers, and adiponectin (APN) protein on bioinert sulfonated polyetheretherketone (sPEEK/GO/APN). The functionalized samples display superior cytocompatibility and in viro osteogenicity regarding cell reproduction, spreading, alkaline phosphatase activity, extracellular matrix calcification, and osteo-associated genes expression, outperforming sPEEK/GO and sPEEK/APN samples. The in vivo evaluation using a rabbit femur defect model demonstrates that the multifunctional coating significantly boosts bone regeneration and osseointegration. More importantly, the GO/pDA complex bonded together through π-π stacking and electrostatic interactions gives rise to robust cyclic photothermal bacteria-killing ability towards both Gram-positive and Gram-negative bacteria. Such a surface engineering platform may enable biomedical implants with enhanced osteogenicity ability and remotely recyclable photo-disinfection, holding great potential in the treatment of incurable infective bone loss. |
Keywords | PEEK; graphene oxide; adiponectin; osteogenicity; photo-disinfection |
ANZSRC Field of Research 2020 | 401605. Functional materials |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Sichuan University, China |
Centre for Future Materials | |
Zhengzhou University, China | |
Southwest Medical University, China | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q599v/graphene-oxide-and-adiponectin-functionalized-sulfonated-polyetheretherketone-with-effective-osteogenicity-and-remotely-repeatable-photo-disinfection
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