Bacteria-triggered pH-responsive osteopotentiating coating on 3D-printed polyetheretherketone scaffolds for infective bone defect repair
Article
Article Title | Bacteria-triggered pH-responsive osteopotentiating coating on 3D-printed polyetheretherketone scaffolds for infective bone defect repair |
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ERA Journal ID | 3890 |
Article Category | Article |
Authors | Deng, Yi (Author), Shi, Xiuyuan (Author), Chen, Yong (Author), Yang, Weizhong (Author), Ma, Yuan (Author), Shi, Xiao-Lei (Author), Song, Pingan (Author), Dargusch, Matthew S. (Author) and Chen, Zhi-Gang |
Journal Title | Industrial and Engineering Chemistry Research |
Journal Citation | 59 (26), pp. 12123-12135 |
Number of Pages | 13 |
Year | 2020 |
Publisher | ACS Publications |
Place of Publication | United States |
ISSN | 0888-5885 |
1520-5045 | |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acs.iecr.0c02107 |
Web Address (URL) | https://pubs.acs.org/doi/10.1021/acs.iecr.0c02107 |
Abstract | Biomaterial-enabled regeneration of the infected or contaminated bone defects remains one of the critical challenges in the development of new clinical treatments. Three-dimensional (3D) porous scaffolds, which can synchronously emulate the hierarchy of bone structures and additionally provide bactericidal and osteogenic features, offer a potential solution to tackle this issue. In this work, we construct hierarchical porous polyetheretherketone (PEEK) scaffolds via 3D printing, equipped with a pH-triggered osteopotentiating coating. In the design of the coating, silver nanoparticles (AgNPs) are trapped onto the first polydopamine (pDA) layer, and apatite is further anchored onto the second pDA layer. The unique “pDA–Ag–pDA” sandwich structure imparts bacteria-triggered pH-responsive ion-releasing behavior to the inert PEEK scaffolds, i.e., the liberation of Ag+ ions from the coating is augmented with decreasing pH value, which is associated with the metabolism of bacteria. These bioscaffolds exhibit excellent capability for eradicating bacteria, as well as harness acceptable cytocompatibility and protuberant osteogenetic potential of osteoblastic MC3T3-E1 cells. Importantly, in vivo evaluation indicates that the Ag/apatite codecorated multifunctional bioscaffolds present appealing in vivo antibacterial efficacy and excellent bone ingrowth and osseointegration in an infected critical-sized bone defect. Accordingly, such “smart” pH-triggered osteopromotive PEEK implants demonstrate strong potential in the treatment of the complicated infective bone disorders. |
Keywords | Silver nanoparticles; surface; phosphate; ions; osseointegration; nanostructures; antibacterial; biomaterials; genotoxicity; mechanisms |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 401605. Functional materials |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Sichuan University, China |
Imperial College London, United Kingdom | |
Western Theater Command General Hospital, China | |
Centre for Future Materials | |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q5w07/bacteria-triggered-ph-responsive-osteopotentiating-coating-on-3d-printed-polyetheretherketone-scaffolds-for-infective-bone-defect-repair
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