The combined therapeutic effects of 131 iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer
Article
Article Title | The combined therapeutic effects of 131 iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer |
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ERA Journal ID | 211597 |
Article Category | Article |
Authors | Liu, Qiufang (Author), Qian, Yuyi (Author), Li, Panli (Author), Zhang, Sihang (Author), Wang, Zerong (Author), Liu, Jianjun (Author), Sun, Xiaoguang (Author), Fulham, Michael (Author), Feng, Dagan (Author), Chen, Zhigang (Author), Song, Shaoli (Author), Lu, Wei (Author) and Huang, Gang (Author) |
Journal Title | Acta Pharmaceutica Sinica B |
Journal Citation | 8 (3), pp. 371-380 |
Number of Pages | 10 |
Year | 2018 |
Publisher | Zhongguo Yixue Kexueyuan Yaowu Yanjiusuo |
Place of Publication | netherlands |
ISSN | 2211-3835 |
2211-3843 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.apsb.2018.04.001 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S2211383517305889 |
Abstract | Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis. In this study, we prepared multifunctional microspheres loading 131I-labeled hollow copper sulfide nanoparticles and paclitaxel (131I-HCuSNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats. 18F-fluordeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging detected that the expansion of the tumor volume was delayed (P<0.05) following intra-tumoral (i.t.) injection with 131I-HCuSNPs-MS-PTX plus near-infrared (NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography (SPECT)/photoacoustic imaging mediated by 131I-HCuSNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that 131I-HCuSNPs-MS-PTX offered combined photothermal, chemo- and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, 131I-HCuSNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model. |
Keywords | microspheres; theranostics; combination therapy; single photon emission computed tomography/computed tomography (SPECT/CT); photoacoustic imaging |
ANZSRC Field of Research 2020 | 401605. Functional materials |
Byline Affiliations | Shanghai Jiao Tong University, China |
Fudan University, China | |
University of Sydney | |
Centre for Future Materials | |
Institution of Origin | University of Southern Queensland |
Funding source | Australian Research Council (ARC) |
https://research.usq.edu.au/item/q5277/the-combined-therapeutic-effects-of-131-iodine-labeled-multifunctional-copper-sulfide-loaded-microspheres-in-treating-breast-cancer
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