Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy
Article
Article Title | Facile synthesis and characterization of multifunctional cobalt-based nanocomposites for targeted chemo-photothermal synergistic cancer therapy |
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ERA Journal ID | 4883 |
Article Category | Article |
Authors | Zhu, Huang (Author), Deng, Jiuhong (Author), Yang, Zhaopu (Author), Deng, Yi (Author), Yang, Weizhong (Author), Shi, Xiao-Lei (Author) and Chen, Zhi-Gang (Author) |
Journal Title | Composites Part B: Engineering |
Journal Citation | 178, pp. 1-9 |
Article Number | 107521 |
Number of Pages | 9 |
Year | 2019 |
Publisher | Elsevier |
Place of Publication | Oxford, United Kingdom |
ISSN | 1359-8368 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.compositesb.2019.107521 |
Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/S1359836819341216 |
Abstract | In this study, we develop polyethylene glycol (PEG) modified nanocomposites, which structurally constitute graphene oxide (GO) and cobalt nanoparticles (CoNPs), called as the CoNPs-GO-PEG nanocomposites. These CoNPs-GO-PEG nanocomposites show better outcomes and less side effects when eliminating tumor cells. After a series of comprehensive characterizations, the CoNPs-GO-PEG nanocomposites are proved to possess pleasing targeting ability and unique drug release behavior, indicating that the concentration of the drug delivered by CoNPs-GO-PEG in the tumor site is much higher than that in the normal tissue, and concerning the favorable biocompatibility of CoNPs-GO-PEG nanocomposites, less harm is caused to normal tissue compared to traditional chemotherapy. Furthermore, because of the satisfactory photothermal effect and favorable drug release behavior of the material, the CoNPs-GO-PEG are able to eradicate most of the tumor cells (99%) through synergistic chemo-photothermal therapy in vitro. So far, our study has demonstrated an inspiring potential for the CoNPs-GO-PEG nanocomposites to act as a favorable targeting multifunctional agent in cancer therapy. |
Keywords | metal-matrix composites (MMCs), photothermal, nano-structures, surface properties, magnetic properties |
ANZSRC Field of Research 2020 | 401605. Functional materials |
Byline Affiliations | Sichuan University, China |
Centre for Future Materials | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q595z/facile-synthesis-and-characterization-of-multifunctional-cobalt-based-nanocomposites-for-targeted-chemo-photothermal-synergistic-cancer-therapy
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