Dual Ag/ZnO-decorated micro-/nanoporous sulfonated polyetheretherketone with superior antibacterial capability and biocompatibility via layer-by-layer self-assembly strategy
Article
Article Title | Dual Ag/ZnO-decorated micro-/nanoporous sulfonated polyetheretherketone with superior antibacterial capability and biocompatibility via layer-by-layer self-assembly strategy |
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ERA Journal ID | 1680 |
Article Category | Article |
Authors | Deng, Yi (Author), Yang, Lei (Author), Huang, Xiaobing (Author), Chen, Junhong (Author), Shi, Xiuyuan (Author), Yang, Weizhong (Author), Hong, Min (Author), Wang, Yuan (Author), Dargusch, Matthew (Author) and Chen, Zhi-Gang (Author) |
Journal Title | Macromolecular Bioscience |
Journal Citation | 18 (7), pp. 1-12 |
Article Number | 1800028 |
Number of Pages | 12 |
Year | 2018 |
Place of Publication | Germany |
ISSN | 1616-5187 |
1616-5195 | |
Digital Object Identifier (DOI) | https://doi.org/10.1002/mabi.201800028 |
Web Address (URL) | https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201800028 |
Abstract | Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated polyetheretherketone surface. The antibacterial assays demonstrate that Ag-decorated sulfonated polyetheretherketone and Ag/ZnO-codecorated sulfonated polyetheretherketone effectively inhibit the reproduction of Gram-negative and Gram-positive bacteria. Owing to the coordination of micro-/nanoscale topological cues and Zn induction, the Ag/ZnO-codecorated sulfonated polyetheretherketone substrates are found to enhance biocompatibility (cell viability, spreading, and proliferation), and hasten osteodifferentiation and -maturation (alkaline phosphate activity (ALP) production, and osteogenesis-related genetic expression), compared with the Ag-decorated sulfonated polyetheretherketone and the ZnO-decorated sulfonated polyetheretherketone counterparts. The dual therapy Ag/ZnO-codecorated sulfonated polyetheretherketone has an appealing bacteriostatic performance and osteogenic differentiation potential, showing great potential for dental and orthopedic implants. |
Keywords | Ag; antibacterial; cytocompatibility; dental and orthopedic implants; polyetheretherketone; ZnO; in-vitro; osteogenic differentiation; bone-formation; biomedical applications; antimicrobial activity; stromal cells; surface; bioactivity; titanium; chitosan |
ANZSRC Field of Research 2020 | 340210. Solid state chemistry |
401807. Nanomaterials | |
Byline Affiliations | Sichuan University, China |
Centre for Future Materials | |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q505y/dual-ag-zno-decorated-micro-nanoporous-sulfonated-polyetheretherketone-with-superior-antibacterial-capability-and-biocompatibility-via-layer-by-layer-self-assembly-strategy
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