Thermoplastic Elastomer-Reinforced Hydrogels with Excellent Mechanical Properties, Swelling Resistance, and Biocompatibility
Article
Liu, Zhanqi, Zhang, Hechuan, Zhou, Ruigang, Gao, Haiyang, Wu, Yongchuan, Wang, Yuqing, Wu, Haidi, Guan, Cheng, Wang, Ling, Tang, Longcheng, Song, Pingan, Xue, Huaiguo and Gao, Jiefeng. 2025. "Thermoplastic Elastomer-Reinforced Hydrogels with Excellent Mechanical Properties, Swelling Resistance, and Biocompatibility." Advanced Science. 12 (12). https://doi.org/10.1002/advs.202414339
Article Title | Thermoplastic Elastomer-Reinforced Hydrogels with Excellent Mechanical Properties, Swelling Resistance, and Biocompatibility |
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ERA Journal ID | 210044 |
Article Category | Article |
Authors | Liu, Zhanqi, Zhang, Hechuan, Zhou, Ruigang, Gao, Haiyang, Wu, Yongchuan, Wang, Yuqing, Wu, Haidi, Guan, Cheng, Wang, Ling, Tang, Longcheng, Song, Pingan, Xue, Huaiguo and Gao, Jiefeng |
Journal Title | Advanced Science |
Journal Citation | 12 (12) |
Article Number | 2414339 |
Number of Pages | 11 |
Year | 2025 |
Publisher | John Wiley & Sons |
Place of Publication | Germany |
ISSN | 2198-3844 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/advs.202414339 |
Web Address (URL) | https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202414339 |
Abstract | Strong and tough hydrogels are promising candidates for artificial soft tissues, yet significant challenges remain in developing biocompatible, anti-swelling hydrogels that simultaneously exhibit high strength, fracture strain, toughness, and fatigue resistance. Herein, thermoplastic elastomer-reinforced polyvinyl alcohol (PVA) hydrogels are prepared through a synergistic combination of phase separation, wet-annealing, and quenching. This approach markedly enhances the crystallinity of the hydrogels and the interfacial interaction between PVA and thermoplastic polyurethane (TPU). This strategy results in the simultaneous improvement of the mechanical properties of the hydrogels, achieving a tensile strength of 11.19 ± 0.80 MPa, toughness of 62.67 ± 10.66 MJ m−3, fracture strain of 1030 ± 106%, and fatigue threshold of 1377.83 ± 62.78 J m−2. Furthermore, the composite hydrogels demonstrate excellent swelling resistance, biocompatibility, and cytocompatibility. This study presents a novel approach for fabricating strong, tough, stretchable, biocompatible, and fatigue- and swelling-resistant hydrogels with promising applications in soft tissues, flexible electronics, and load-bearing biomaterials. |
Keywords | hydrogels; Thermoplastic |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 401609. Polymers and plastics |
Byline Affiliations | Yangzhou University, China |
University of Florida, United States | |
Anqing Normal University, China | |
Hangzhou Normal University, China | |
Centre for Future Materials |
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Advanced Science - 2025 - Liu - Thermoplastic Elastomer‐Reinforced Hydrogels with Excellent Mechanical Properties Swelling.pdf | ||
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