Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications
Article
Article Title | Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications |
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ERA Journal ID | 40638 |
Article Category | Article |
Authors | Vu, Trung-Hieu, Yadav, Sharda, Tran, Canh-Dung, Nguyen, Hong-Quan, Nguyen, Tuan-Hung, Nguyen, Thanh, Nguyen, Tuan-Khoa, Fastier-Wooller, Jarred W., Dinh, Toan, Phan, Hoang-Phuong, Ta, Hang Thu, Nguyen, Nam-Trung, Dao, Dzung Viet and Dau, Van Thanh |
Journal Title | ACS Applied Materials and Interfaces |
Journal Citation | 15 (25), pp. 29777-29788 |
Number of Pages | 12 |
Year | 2023 |
Publisher | American Chemical Society |
Place of Publication | United States |
ISSN | 1944-8244 |
1944-8252 | |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acsami.3c02000 |
Web Address (URL) | https://pubs.acs.org/doi/abs/10.1021/acsami.3c02000 |
Abstract | Electrohydrodynamic atomization (EHDA) provides unparalleled control over the size and production rate of particles from solution. However, conventional methods produce highly charged particles that are not appropriate for inhalation drug delivery. We present a self-propelled EHDA system to address this challenge, a promising one-step platform for generating and delivering charge-reduced particles. Our approach uses a sharp electrode to produce ion wind, which reduces the cumulative charge in the particles and transports them to a target in front of the nozzle. We effectively controlled the morphologies of polymer products created from poly(vinylidene fluoride) (PVDF) at various concentrations. Our technique has also been proven safe for bioapplications, as evidenced by the delivery of PVDF particles onto breast cancer cells. The combination of simultaneous particle production and charge reduction, along with its direct delivery capability, makes the self-propelled EHDA a versatile technique for drug delivery applications |
Keywords | electrohydrodynamic atomization, charge-reduced particles, single-step EHDA, ion wind, single-step drug delivery, electrospray |
ANZSRC Field of Research 2020 | 510303. Electrostatics and electrodynamics |
401705. Microelectromechanical systems (MEMS) | |
510501. Biological physics | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Griffith University |
University of Southern Queensland | |
University of New South Wales | |
University of Queensland |
https://research.usq.edu.au/item/z2z3q/charge-reduced-particles-via-self-propelled-electrohydrodynamic-atomization-for-drug-delivery-applications
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